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Trequinsin hydrochloride
CAS No. 78416-81-6
Trequinsin hydrochloride( HL 725 )
Catalog No. M15958 CAS No. 78416-81-6
Trequinsin hydrochloride (HL 725) is a potent, cell-permeable, orally active inhibitor of cGMP-inhibited phosphodiesterase (PCE3 IC50=250 pM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 50MG | 740 | Get Quote |
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| 100MG | 1224 | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameTrequinsin hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionTrequinsin hydrochloride (HL 725) is a potent, cell-permeable, orally active inhibitor of cGMP-inhibited phosphodiesterase (PCE3 IC50=250 pM).
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DescriptionTrequinsin hydrochloride (HL 725) is a potent, cell-permeable, orally active inhibitor of cGMP-inhibited phosphodiesterase (PCE3 IC50=250 pM), inhibits arachidonic acid-induced aggregation of human platelets with IC50 of 50 pM; reduces systemic blood pressure in both normotensive and hypertensive animal models.Hypertension Discontinued.
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In VitroTrequinsin hydrochloride exerts besides its cardiovascular and antihypertensive qualities very potent antiplatelet activities.Trequinsin hydrochloride is an efficacious agonist of [Ca2+]i. Cell Viability Assay Cell Line:Samples from healthy volunteer research donors with normal sperm motility parameters in agreement with World Health Organization 2010 criteria.Concentration:10 μM.Incubation Time:20 min.Result:Caused a concentration dependent increase in [Ca2+]i (EC50 = 6.4 μM [95% confidence interval (CI): 4.1-9.9 μM]).
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In Vivo——
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SynonymsHL 725
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PathwayAngiogenesis
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TargetPDE
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RecptorPDE
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Research AreaCardiovascular Disease
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IndicationHypertension
Chemical Information
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CAS Number78416-81-6
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Formula Weight441.956
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Molecular FormulaC24H28ClN3O3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 62.5 mg/mL (141.42 mM)
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SMILESCC1=CC(=C(C(=C1)C)N=C2C=C3C4=CC(=C(C=C4CCN3C(=O)N2C)OC)OC)C.Cl
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Chemical Name2,3,6,7-Tetrahydro-9,10-dimethoxy-3-methyl-2-[(2,4,6-trimethylphenyl)imino]-4H-pyrimido[6,1-a]isoquinolin-4-one hydrochloride
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Lal B, et al. J Med Chem. 1984 Nov;27(11):1470-80.
2. Ruppert D, et al. Life Sci. 1982 Nov 8;31(19):2037-43.
3. Darius H, et al. Br J Pharmacol. 1985 Mar;84(3):735-41.
4. Blaskó G, et al. Thromb Res. 1986 Jul 15;43(2):249-50.
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